PTRS 780 CENTRAL NERVOUS SYSTEM PLASTICITY
This course explores published experimental evidence characterizing plasticity during the development of the nervous system, normal neuronal and glial functions, and the mechanisms underlying recovery of neurological function following central or peripheral nerve injuries. Students read and discuss classic original literature and formulate theoretical constructs for the role of physical rehabilitation interventions designed to promote or simplify plasticity within the nervous system. Lecture and discussion topics include a historical overview of regeneration and plasticity research, collateral sprouting, denervation super-sensitivity, synaptic redundancy, axonal regeneration, synaptogenesis, competitive interactions, behavioral substitution, and critical periods. Prerequisites: basic neuroscience course